Exhaled breath 8-isoprostane as a marker of asthma severity
نویسندگان
چکیده
منابع مشابه
Exhaled breath 8-isoprostane as a marker of asthma severity
INTRODUCTION Oxidative stress is a non-specific feature of airway inflammation in asthmatics. 8-Isoprostane (8-IP), a prostaglandin-F(2α) isomer, is a relatively new marker of oxidative stress and may be measured in exhaled breath condensate (EBC) of patients with asthma. This research study aimed to evaluate the usefulness of EBC 8-IP as a marker of severity and control of severe adult asthma....
متن کاملExhaled 8-isoprostane in childhood asthma
BACKGROUND Exhaled breath condensate (EBC) is a non-invasive method to assess airway inflammation and oxidative stress and may be useful in the assessment of childhood asthma. METHODS Exhaled 8-isoprostane, a stable marker of oxidative stress, was measured in EBC, in children (5-17 years) with asthma (13 steroid-naïve and 12 inhaled steroid-treated) and 11 healthy control. RESULTS Mean exha...
متن کاملIncreased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients.
Oxidative stress has an important role in the pathogenesis of asthma. 8-Isoprostane is a prostaglandin (PG)-F2-like compound belonging to the F2 isoprostane class that is produced in vivo by the free radical-catalyzed peroxidation of arachidonic acid. 8-Isoprostane is a biomarker of oxidative stress, and its concentration is increased in the bronchoalveolar lavage fluid of patients with interst...
متن کاملLeukotriene B4 and 8-isoprostane in exhaled breath condensate of children with episodic and persistent asthma.
BACKGROUND Leukotrienes and isoprostanes are biomarkers of airway inflammation and oxidative stress that can be detected in exhaled breath condensate (EBC). The aim of this study was to evaluate leukotriene B4 (LTB4) and 8-isoprostane levels in EBC of healthy and asthmatic children with episodic and moderate persistent asthma. METHODS EBC was collected from 62 children aged 6 to 14 years: 22 ...
متن کاملCysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations.
BACKGROUND Cysteinyl leukotrienes (Cys-LTs) and isoprostanes are inflammatory metabolites derived from arachidonic acid whose levels are increased in the airways of asthmatic patients. Isoprostanes are relatively stable and specific for lipid peroxidation, which makes them potentially reliable biomarkers for oxidative stress. A study was undertaken to evaluate the effect of a course of oral ste...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2012
ISSN: 1734-1922
DOI: 10.5114/aoms.2012.28639